Epitopes are the immunogenic antigen peptides, continuous or noncontinuous amino acid sequences, recognized by immune cells. Understanding cancer immunotherapy, as well as developing vaccines and targeted therapies, requires a thorough understanding of the molecular characteristics of epitopes within cancer antigens. Cellular and humoral immunity are validated to provide principal protection after epitope recognition. CD4+ and CD8+ T cells could separately recognize pathogenic epitopes presented by MHC I and MHC II molecules on antigen-presenting cells. BCRs and antibodies bind to the exposed solvent parts of the antigen. With rich knowledge and experience in immune responses of B cells and T cells to antigen/epitope, Creative Biolabs offers various B cell and T cell-based assays for cancer epitope analysis.
We can detect the epitope-specific adaptive immune responses based on antigen-specific receptors expressed on the surfaces of T- and B-lymphocytes using advanced equipment and technologies. Our services include:
Immune cell types and cell biological activities are used to categorize services. Depending on your subject, you can use a single assay or a combination of assays to analyze cancer epitopes. We offer the following assay services. If you do not see any services that suit your needs, please contact us for a personalized inquiry.
T CELL-BASED ASSAYS
Proliferation Assays
Cytotoxicity Assays
Binding Kinetics Assays
Inflammatory Cytokines Release Assays
Activation, Degranulation, Antibody help Assay
Suppression Assay
Type IV hypersensitivity (DTH) Assay
3D Structure Assay
Disease State, Pathogen burden, Survival Before and After Adoptive Transfer Assay
B CELL-BASED ASSAYS
Qualitative Binding Assays
Quantitative Binding (Dissociation Constant KD, Association Constant KA, Off Rate, On Rate) Assays
Antibody Activity, Cellular Cytotoxicity, Antigen Activation, Neutralization Assay
In Vivo Activity, Hemagglutination Inhibition, Opsonization, Agglutination Assay
3D Structure Assays
Disease State, Tumor Burden, Survival Before and After Adoptive Transfer Assay
Fig.2 Our strengths in cancer epitope analysis. (Creative Biolabs)
Creative Biolabs is a reliable service provider with thousands of satisfied customers and a trusted partner for antigen epitope discovery. We collaborate closely with our clients and provide tailored solutions to meet their specific needs. If you are interested in our services, please contact us so that we can discuss your project with our skilled professionals.
For Research Use Only | Not For Clinical Use
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