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GlycoFlux™ Human AGL Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF608

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human AGL overexpression HepG2 cell line is a stable cell line engineered to express AGL, the glycogen debranching enzyme with dual 4-α-glucanotransferase and amylo-1,6-glucosidase activities. Essential for glycogen breakdown, mutations cause glycogen storage disease III with variable presentations. This model supports research on glycogen metabolism, liver and muscle physiology, and therapeutic intervention strategies.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
AGL
Full Name
Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase
Alternative Name
GDE
Location
1p21.2
Gene ID
178
Summary
This gene encodes the glycogen debranching enzyme, critical for glycogen breakdown. It carries two separate catalytic activities-4-alpha-glucanotransferase and amylo-1,6-glucosidase-at different sites. Mutations cause glycogen storage diseases, with variability likely influenced by tissue-specific alternative splicing. Distinct isoforms arise from alternative splicing.
For Research Use Only.
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