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GlycoFlux™ Human SIGLEC12 Overexpression CHO-K1 Cell Line

CAT#: GLJF-0925-JF857

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC12 overexpression CHO-K1 cell line is a stable cell line overexpressing SIGLEC12, a sialic acid-binding receptor of the SIGLEC3-like subfamily with Ig-like extracellular domains and intracellular ITIM motifs. It acts as an inhibitory receptor dampening macrophage activation. This platform enables analysis of ITIM-dependent inhibitory signaling, glycoimmunology, and host-pathogen glycan interactions.
Product Type
Overexpression Cell Lines
Species
Hamster
Cell Morphology
Epithelial, adherent
Passage Ratio
1:3~1:5
Cell Line
CHO-K1
Lineage
Chinese hamster ovary
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC12
Full Name
Sialic Acid Binding Ig Like Lectin 12
Alternative Name
S2V, SLG, SIGLECL1, Siglec-XII, Sialic Acid Binding Ig Like Lectin
Summary
This gene encodes a member of the SIGLEC3-like subfamily, characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set domains, and cytoplasmic motifs ITIM and SLAM-like. Upon tyrosine phosphorylation, the protein recruits SHP1 and SHP2, and functions as an inhibitory receptor to negatively regulate macrophage signaling. This gene is clustered with other SIGLEC3-like genes on 19q13.4, and alternative splicing results in multiple transcript variants.
For Research Use Only.
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