Recombinant Avian sarcoma virus (strain UR2) Envelope glycoprotein (ENV), E. coli (CAT#: GPX-023-E-J)

Product Overview	Recombinant Avian sarcoma virus (strain UR2) Envelope glycoprotein was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	E. coli
Species	Avian sarcoma virus (strain UR2)
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	ENV
Full Name	Envelope glycoprotein
Uniprot ID	P03398
Background	The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
Alternate Names	Envelope glycoprotein; Env polyprotein; Transmembrane protein; TM; Glycoprotein 37; gp37