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Recombinant Human GDNF protein (NP_000505.1) is produced in Sia-Increased Human Cell Line. This expression system is used for the production of glycoproteins with high sialylation with fucosylation.
The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy.