Recombinant Jaagsiekte sheep retrovirus (JSRV) Envelope glycoprotein (ENV), Mammalian cell (CAT#: GPX-266-M-J)

Product Overview	Recombinant Jaagsiekte sheep retrovirus (JSRV) Envelope glycoprotein (NP_041188.1) was expressed in Mammalian cell with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	Mammalian cell
Species	Jaagsiekte sheep retrovirus (JSRV)
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	ENV
Full Name	Envelope glycoprotein
Gene ID	1490021
Uniprot ID	P31621
Accession Number	NP_041188.1
Background	The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2.
Alternate Names	Envelope glycoprotein; Env polyprotein; Surface protein; SU; Glycoprotein 52; gp52; Transmembrane protein; TM; Glycoprotein 36; gp36