GlycoErase™ CPT2 Knockout HEK293 Cell Line

GlycoErase™ CPT2 knockout HEK293 cell line is a human embryonic kidney (HEK293) model lacking CPT2 expression. CPT2 is a mitochondrial protein that, together with CPT1, catalyzes long-chain fatty acid oxidation within the mitochondrial inner membrane. Defects in CPT2 cause fatty acid oxidation disorders. Removal of CPT2 in the HEK293 background provides a human-based system to study mitochondrial fatty acid metabolism, energy homeostasis, and metabolic disease mechanisms, supporting applications in mitochondrial biology, lipid metabolism, and rare disease research.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & Proline & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

CPT2

Carnitine Palmitoyltransferase 2

CPT1; IIAE4; CPTASE

1p32.3

This nuclear protein is transported to the mitochondrial inner membrane, where it cooperates with carnitine palmitoyltransferase I to oxidize long-chain fatty acids. Defects are linked to mitochondrial long-chain fatty acid oxidation disorders.