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GlycoFlux™ Human LDHA Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF646

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human LDHA overexpression HepG2 cell line is a stable cell line engineered to express lactate dehydrogenase A (LDHA), the skeletal muscle-predominant isoform catalyzing pyruvate-to-lactate conversion during anaerobic glycolysis. Mutations are associated with exertional myoglobinuria, while aberrant LDHA activity drives tumor glycolysis (Warburg effect). This model provides a platform for cancer metabolism, hypoxia adaptation, and therapeutic intervention studies.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
LDHA
Full Name
Lactate Dehydrogenase A
Alternative Name
LDHM; GSD11; PIG19; HEL-S-133P
Location
11p15.1
Gene ID
3939
Summary
This gene encodes the A chain of lactate dehydrogenase, which catalyzes the reversible conversion of pyruvate to lactate with concurrent oxidation of NADH to NAD during anaerobic glycolysis. Predominantly expressed in skeletal muscle, it belongs to the lactate dehydrogenase family. Mutations have been linked to exertional myoglobinuria. Several nonfunctional pseudogenes exist in the human genome.
For Research Use Only.
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