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GlycoFlux™ Human SIGLEC2 Overexpression CHO-K1 Cell Line

CAT#: GLJF-0925-JF881

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC2 overexpression CHO-K1 cell line is a stable cell line designed to overexpress SIGLEC2, a sialic acid-binding immunoglobulin receptor that mediates CD4 receptor binding and protein phosphatase recruitment. Located in early and recycling endosomes, it controls B-cell activation and receptor signaling attenuation, with roles in lymphomagenesis. This model supports glycan interaction research and immune-oncology studies using a robust non-human background.
Product Type
Overexpression Cell Lines
Species
Hamster
Cell Morphology
Epithelial, adherent
Passage Ratio
1:3~1:5
Cell Line
CHO-K1
Lineage
Chinese hamster ovary
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC2
Full Name
Sialic Acid Binding Ig Like Lectin 2
Alternative Name
SIGLEC-2, CD22, Sialic Acid Binding Ig Like Lectin
Summary
The protein is predicted to exhibit CD4 receptor binding activity, protein phosphatase binding activity, and sialic acid binding activity. It is involved in B cell activation, negative regulation of the B cell receptor signaling pathway, and regulation of endocytosis. The protein is located in early and recycling endosomes and is implicated in diffuse large B-cell lymphoma.
For Research Use Only.
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