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GlycoFlux™ Human SIGLEC2 Overexpression HEK293 Cell Line

CAT#: GLJF-0925-JF882

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC2 overexpression HEK293 cell line is a stable line expressing SIGLEC2, a receptor with CD4 and phosphatase binding activities that regulates B-cell activation, signaling downregulation, and endocytosis. Found in early and recycling endosomes, SIGLEC2 has been linked to diffuse large B-cell lymphoma. This glycoengineered platform enables exploration of immune regulation, lectin-glycan biology, and therapeutic targeting in B-cell malignancies.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC2
Full Name
Sialic Acid Binding Ig Like Lectin 2
Alternative Name
SIGLEC-2, CD22, Sialic Acid Binding Ig Like Lectin
Location
19q13.12
Gene ID
8778
Summary
This protein is predicted to bind CD4 receptors, protein phosphatases, and sialic acid. It is involved in the activation of B cells, suppression of B cell receptor signaling, and the regulation of endocytosis. The protein is found in early and recycling endosomes and is associated with diffuse large B-cell lymphoma.
For Research Use Only.
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