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GlycoErase™ SIGLEC2 Knockout Glycoengineered Cell

CAT#: GLJF-0825-JF118

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ SIGLEC2 knockout glycoengineered cell disrupts Siglec-2 (CD22), a sialic acid-binding lectin that regulates B cell receptor signaling and endocytosis. Implicated in B-cell lymphoma, this model supports research in B-cell biology and cancer immunology.
Product Type
KO Cell Lines
Cell Line
As requested by the client.
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC2
Full Name
Sialic Acid Binding Ig Like Lectin 2
Alternative Name
SIGLEC-2; CD22; Sialic Acid Binding Ig Like Lectin
Location
19q13.12
Gene ID
8778
Summary
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. Implicated in diffuse large B-cell lymphoma.
For Research Use Only.
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