GlycoErase™ SIGLEC2 Knockout HEK293 Cell Line

GlycoErase™ SIGLEC2 knockout HEK293 cell line is a human embryonic kidney cell line lacking SIGLEC2 expression. SIGLEC2 acts as a sialic acid-binding receptor involved in CD4 receptor interactions, B-cell activation, receptor signaling, and endocytosis, and it has been linked to diffuse large B-cell lymphoma. This knockout HEK293 model offers a useful platform for investigating immune receptor pathways, endosomal trafficking, and B-cell-related mechanisms, with applications in functional genomics, antibody research, and viral studies.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & Proline & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC2

Sialic Acid Binding Ig Like Lectin 2

SIGLEC-2, CD22, Sialic Acid Binding Ig Like Lectin

19q13.12

This protein is predicted to bind CD4 receptors, protein phosphatases, and sialic acid. It is involved in the activation of B cells, suppression of B cell receptor signaling, and the regulation of endocytosis. The protein is found in early and recycling endosomes and is associated with diffuse large B-cell lymphoma.