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GlycoErase™ MAN2B1 Knockout Human Malignant Melanoma Cell A375

CAT#: GLJF-0525-JF1208

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Overview Specification Target Information Related Products
Overview
Description
The MAN2B1 knockout A375 cell line, deficient in mannosidase alpha class 2B member 1 involved in the catabolism of N-linked carbohydrates, allows for the investigation of carbohydrate catabolism disruption in melanoma, potentially affecting N-glycan turnover, lysosomal glycan processing, and cellular nutrient recycling, which are critical in melanoma cell metabolism.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:3~1:4
Cell Line
A375
Primary Disease
Melanoma
Lineage
Skin
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
MAN2B1
Full Name
Mannosidase alpha class 2B member 1
Alternative Name
LAMAN, MANB
Location
19p13.13
Gene ID
4125
Summary
Hydrolyzes terminal alpha-D-mannose residues in alpha-D-mannosides; essential for N-linked carbohydrate catabolism during glycoprotein turnover.
For Research Use Only.
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