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GlycoErase™ MGAT2 Knockout Human Kidney Clear Cell Carcinoma Cell 786-O

CAT#: GLJF-0525-JF572

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Overview Specification Target Information Related Products
Overview
Description
The MGAT2 knockout human kidney clear cell carcinoma cell 786-O line, lacking mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase involved in complex N-glycan synthesis, allows for the investigation of complex N-glycan disruption in renal carcinoma, potentially affecting N-glycan processing and downstream glycoprotein functions relevant to tumor biology.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
786-O
Primary Disease
Renal Cell Carcinoma
Lineage
Kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
MGAT2
Full Name
Alpha-1,6-mannosyl-glycoprotein 2-Beta-O-acetylglucosaminyltransferase
Alternative Name
GNT-II
Location
14q21.3
Gene ID
4247
Summary
Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans; possesses typical glycosyltransferase domains.
For Research Use Only.
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