GlycoErase™ MGAT2 Knockout Human Skin Cancer Cell A2058 (CAT#: GLJF-0525-JF956)

Description	The MGAT2 knockout A2058 cell line, lacking mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase involved in complex N-glycan synthesis, allows for the investigation of complex N-glycan disruption in melanoma, potentially affecting N-glycan processing and downstream glycoprotein functions relevant to tumor biology in melanoma.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial cells, adherent
Passage Ratio	1:2~1:3
Cell Line	A2058
Primary Disease	Melanoma
Lineage	Skin

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	EMEM & FBS & Glutamine
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	MGAT2
Full Name	Alpha-1,6-mannosyl-glycoprotein 2-Beta-O-acetylglucosaminyltransferase
Alternative Name	GNT-II
Location	14q21.3
Gene ID	4247
Summary	Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans; possesses typical glycosyltransferase domains.