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GlycoErase™ PPP2CA Knockout Jurkat Cell Line

CAT#: GLJF-0825-JF816

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ PPP2CA knockout Jurkat cell line is a Jurkat model in which PPP2CA, the α catalytic subunit of protein phosphatase 2A (PP2A), has been eliminated. PP2A is a major Ser/Thr phosphatase that negatively regulates cell growth and division via diverse regulatory subunits. The knockout enables analysis of PP2A-dependent tumor suppression, cell-cycle phosphoregulation, and phosphatase inhibitor responses in a controllable Jurkat background.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Suspension-growing
Passage Ratio
1:3~1:5
Cell Line
Jurkat cell line
Primary Disease
T-cell acute lymphoblastic leukemia (T-ALL)
Lineage
T Lymphocyte
Lineage Subtype
T-cell acute lymphoblastic leukemia (T-ALL)
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PPP2CA
Full Name
Protein Phosphatase 2 Catalytic Subunit Alpha
Alternative Name
HJS3; RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha
Location
5q31.1
Gene ID
5515
Summary
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
For Research Use Only.
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