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GlycoFlux™ Human PPP2CA Overexpression HEK293T Cell Line

CAT#: GLJF-0925-JF584

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human PPP2CA overexpression HEK293T cell line is a stable glycoengineered line that constitutively overexpresses the PP2A catalytic α subunit, a core serine/threonine phosphatase controlling growth signals. This platform is suited to map PP2A-driven phosphoregulation of glycosylation machinery-altering branching, core fucosylation, and secretion quality of recombinant proteins.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293T
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Penicillin/Streptomycin
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PPP2CA
Full Name
Protein Phosphatase 2 Catalytic Subunit Alpha
Alternative Name
HJS3; RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha
Location
5q31.1
Gene ID
5515
Summary
This gene encodes the alpha isoform of the catalytic subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase. PP2A acts as a negative regulator of cell growth and division through a heteromeric core structure associated with variable regulatory subunits.
For Research Use Only.
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