GlycoErase™ SIGLEC11 Knockout A549 Cell Line

GlycoErase™ SIGLEC11 knockout A549 cell line is a human lung epithelial cancer model in which SIGLEC11 expression has been eliminated. SIGLEC11 is a sialic acid-binding immunoglobulin-like lectin characterized by Ig-like structural domains and specific sialic acid recognition motifs. It is known to mediate anti-inflammatory and immunosuppressive signaling, and multiple isoforms have been reported. Removing SIGLEC11 in the A549 background provides a relevant model to explore immune suppression pathways, inflammation control, and isoform-specific biology, while enabling applications in immunology research, therapeutic antibody development, and translational drug discovery.

KO Cell Lines

Human

Epithelial-like, adherent

1:3~1:6

A549

Non-small cell lung cancer

Lung

Non-small cell lung cancer

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

F-12K & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC11

Sialic Acid Binding Ig Like Lectin 11

Sialic Acid Binding Ig Like Lectin

19q13.33

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.