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GlycoFlux™ Human PHKA1 Overexpression HEK293 Cell Line

CAT#: GLJF-0925-JF435

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human PHKA1 overexpression HEK293 cell line expresses PHKA1, the skeletal muscle α-subunit of phosphorylase kinase that regulates glycogen breakdown. Mutations cause glycogen storage disease IXd, making this line useful for myopathy and glycogen regulation studies.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PHKA1
Full Name
Phosphorylase Kinase Regulatory Subunit Alpha 1
Alternative Name
PHKA
Location
Xq13.1
Gene ID
5255
Summary
Phosphorylase kinase is a complex with subunits alpha, beta, gamma, and delta. The alpha subunit has isoforms in muscle and liver, with the skeletal muscle isoform encoded by this gene. Mutations cause glycogen storage disease type 9D. Several isoforms exist due to alternative splicing.
For Research Use Only.
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