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GlycoFlux™ Human SIGLEC15 Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF872

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC15 overexpression HepG2 cell line is a stable hepatocyte-like model expressing SIGLEC15, a receptor involved in regulating cytoskeleton dynamics, osteoclast development, and bone metabolism. Localized at the plasma membrane, it participates in signaling complexes that bridge immunity and skeletal regulation. This model provides opportunities for studying liver-associated regulation of bone-immune cross-talk and glycosylation-driven processes.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC15
Full Name
Sialic Acid Binding Ig Like Lectin 15
Alternative Name
CD33L3, HsT1361, SIGLEC-15, Sialic Acid Binding Ig Like Lectin
Location
18q21.1
Gene ID
284266
Summary
This protein is predicted to regulate actin cytoskeleton organization, bone resorption, and osteoclast development. It is expected to be located in the membrane and to be part of a protein-containing complex, functioning actively in the plasma membrane.
For Research Use Only.
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