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GlycoErase™ SIGLEC15 Knockout Jurkat Cell Line

CAT#: GLJF-0825-JF873

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ SIGLEC15 knockout Jurkat cell line is a Jurkat T lymphocyte model lacking SIGLEC15 expression. SIGLEC15 is predicted to regulate actin cytoskeleton organization, bone resorption, and osteoclast development. The knockout Jurkat system provides a platform for studying cytoskeletal regulation in immune cells, T cell signaling pathways, and skeletal-immune interactions, supporting applications in immunotherapy research, apoptosis studies, and drug screening.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Suspension-growing
Passage Ratio
1:3~1:5
Cell Line
Jurkat cell line
Primary Disease
T-cell acute lymphoblastic leukemia (T-ALL)
Lineage
T Lymphocyte
Lineage Subtype
T-cell acute lymphoblastic leukemia (T-ALL)
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC15
Full Name
Sialic Acid Binding Ig Like Lectin 15
Alternative Name
CD33L3, HsT1361, SIGLEC-15, Sialic Acid Binding Ig Like Lectin
Location
18q21.1
Gene ID
284266
Summary
The protein is predicted to regulate actin cytoskeleton organization, bone resorption, and osteoclast development. It is expected to be located in the membrane, forming part of a protein-containing complex, and active in the plasma membrane.
For Research Use Only.
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