GlycoErase™ SIGLEC15 Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF871)

Description	GlycoErase™ SIGLEC15 knockout HEK293T cell line is a human embryonic kidney-derived HEK293T line where SIGLEC15 expression has been removed. SIGLEC15 is predicted to regulate actin cytoskeleton organization, bone resorption, and osteoclast development. The knockout HEK293T background provides a high-expression platform to study osteoclast biology, skeletal disease pathways, and cytoskeletal regulation, and supports applications in therapeutic validation, viral vector systems, and immune modulation research.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC15
Full Name	Sialic Acid Binding Ig Like Lectin 15
Alternative Name	CD33L3, HsT1361, SIGLEC-15, Sialic Acid Binding Ig Like Lectin
Location	18q21.1
Gene ID	284266
Summary	Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.