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Recombinant HHV-5 (strain AD169) Unique short US6 glycoprotein (US6), Baculovirus

CAT#: GPX-151-B-J

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Specifications Target Information Related Products
Specifications
Product Overview
Recombinant Human herpesvirus 5 (strain AD169) (HHV-5) Unique short US6 glycoprotein was expressed in Baculovirus with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity
Determined by its binding ability in a functional ELISA.
Source
Baculovirus
Species
Human herpesvirus 5 (strain AD169) (HHV-5)
Tag
His-tag or Tag free
Purity
>90%, determined by SDS-PAGE.
Conjugation
Unconjugated
Target Information
Target
US6
Full Name
Unique short US6 glycoprotein
Uniprot ID
P14334
Background
Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP). Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2. Also prevents the conformational rearrangement of TAP induced by peptide binding. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Alternate Names
US6; Unique short US6 glycoprotein; Protein HXLF6; gpUS6
For Research Use Only.
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