Recombinant HHV-5 (strain AD169) Unique short US6 glycoprotein (US6), E. coli, Biotin conjugation (CAT#: GPX-151-EB-J)

Product Overview	Recombinant Human herpesvirus 5 (strain AD169) (HHV-5) Unique short US6 glycoprotein was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	E. coli
Species	Human herpesvirus 5 (strain AD169) (HHV-5)
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Biotin

Target	US6
Full Name	Unique short US6 glycoprotein
Uniprot ID	P14334
Background	Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP). Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2. Also prevents the conformational rearrangement of TAP induced by peptide binding. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Alternate Names	US6; Unique short US6 glycoprotein; Protein HXLF6; gpUS6