Recombinant Measles virus (strain Halle) (MeV) Hemagglutinin glycoprotein (1-617 aa), E. coli

Recombinant Measles virus (strain Halle) (MeV) Hemagglutinin glycoprotein (1-617 aa) was produced using E. coli cell-free expression system with a His-tag or Tag free. Measured by its binding ability in a functional ELISA.

Measured by its binding ability in a functional ELISA.

E. coli cell-free expression system

Measles virus (strain Halle) (MeV)

1-617 aa

His-tag or Tag free

>90%, determined by SDS-PAGE.

Unconjugated

H

Hemagglutinin glycoprotein

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.

Hemagglutinin glycoprotein