GlycoErase™ B3GNT2 Knockout KD Cell Line

The B3GNT2 knockout KD cell line, derived from an extra-cranial rhabdoid tumor, lacks B3GNT2 protein, UDP-GlcNAc:betaGal beta-1,3-O-acetylglucosaminyltransferase 2 involved in poly-N-acetyllactosamine chain biosynthesis. B3GNT2 knockout in rhabdoid cancer cells allows investigation of poly-N-acetyllactosamine chain disruption in this pediatric sarcoma, potentially affecting complex glycan structures, cell surface properties and poly-N-acetyllactosamine dependent functions in rhabdoid tumor cells.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

KD cell line

Rhabdoid cancer

Soft Tissue

Rhabdoid cancer

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

F-12 & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

B3GNT2

UDP-GlcNAc:BetaGal Beta-1,3-O-acetylglucosaminyltransferase 2

B3GNT1, BETA3GNT, B3GN-T1, B3GNT-2, B3GN-T2

2p15

Type II transmembrane protein that prefers lacto-N-neotetraose as a substrate and participates in the biosynthesis of poly-N-acetyllactosamine chains.