GlycoErase™ C1GALT1C1 Knockout Human Bladder Cancer Cell 5637

The human bladder bancer bell 5637 line with a C1GALT1C1 gene knockout is of significant importance for unraveling the regulatory mechanisms governing C1GALT1 and O-glycosylation processes in bladder cancer; the C1GALT1C1 deficiency has the potential to modulate C1GALT1 activity, allowing researchers to elucidate the intricacies of O-glycosylation regulation, examine the influence of the C1GALT1/C1GALT1C1 axis on cellular signaling cascades and immune cell interactions within the tumor microenvironment, and to explore therapeutic interventions directed at this regulatory axis.

KO Cell Lines

Human

Epithelial-like, adherent

1:3~1:6

5637

Bladder Urothelial Carcinoma

Bladder/Urinary Tract

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

C1GALT1C1

C1GALT1 specific chaperone 1

C1GALT2, COSMC

Xq24

Facilitates the synthesis of the core-1 O-glycan structure (Thomsen-Friedenreich antigen) by acting as a chaperone for core 1 beta1,3-galactosyltransferase 1, ensuring proper folding and activity of this key enzyme.