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GlycoFlux™ Human PGK1 Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF663

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human PGK1 overexpression HepG2 cell line is a stable glycoengineered line that constitutively overexpresses phosphoglycerate kinase 1, which catalyzes 1,3-bisphosphoglycerate → 3-phosphoglycerate and moonlights as a secreted angiogenesis cofactor. Use it to link ATP generation and secreted PGK1 levels to glycan-dependent secretion, extracellular stability, and receptor engagement, and to profile how UDP-sugar availability alters hepatic secretome glyco-codes.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PGK1
Full Name
Phosphoglycerate Kinase 1
Alternative Name
PGKA; MIG10; HEL-S-68p
Location
Xq21.1
Gene ID
5230
Summary
The encoded protein catalyzes the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate in glycolysis and can act as a cofactor for polymerase alpha. It is also secreted by tumor cells to promote angiogenesis via angiostatin generation. Deficiency can cause hemolytic anemia and neurological symptoms. Pseudogenes are found on chromosomes 19, 21, and X.
For Research Use Only.
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