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L-Fucose Synthesis Service

L-Fucose Synthesis Service: Securing the Future of Functional Glycomics!

Are you currently facing significant, high-purity rare sugar supply limitations that are critical for advanced product development? Our L-fucose synthesis service helps you accelerate time-to-market for advanced nutraceuticals and products through advanced metabolic engineering and biocatalysis. L-Fucose is a uniquely functional deoxyhexose. However, the traditional supply chain, plagued by low yields from algae extraction and complex chemical routes, creates an unacceptable bottleneck for industrial applications. Creative Biolabs provides reliable and high-purity L-fucose tailored to your specific end-product needs. Our solution is grounded in optimizing microbial pathways, ensuring a sustainable, scalable, and environmentally friendly production method that meets strict regulatory standards. We translate complex glycobiology into a simplified, guaranteed supply.

Structural diagram of L-Fucose. (Creative Biolabs Original)Fig.1 The structure of L-Fucose.

Workflow: From Concept to Commercial Supply

To initiate the service and ensure precise targeting of your needs, we require:

  • Target purity profile: Required L-fucose purity percentage and specifications for residual contaminants.
  • Required volume/scale: Estimated annual volume demand (e.g., kg/year or metric tons/year) to select the appropriate production strategy.
  • Specific oligosaccharide precursor: If the L-fucose is destined for further fucosylation or HMO synthesis, specify the target precursor (e.g., 2'-FL, 3'-FL).

Our comprehensive, scalable process ensures total control over purity and yield, designed for seamless integration into your product development pipeline.

Key Step Description Expected Outcome
Biocatalyst & Pathway Design In-depth analysis of your target specifications (purity, volume) to select and engineer the optimal enzyme system (e.g., L-fucose isomerase) or microbial strain. A high-performance, genetically optimized biocatalyst blueprint for maximum conversion efficiency.
Metabolic Engineering & Strain Optimization Implementing advanced genetic modifications in host organisms (e.g., E. coli) to channel low-cost carbon sources directly into the L-fucose biosynthetic pathway. A robust, high-yielding "cell factory" validated in small-scale fermentation runs, ready for scale-up optimization.
Fermentation Process Scale-Up Optimization of bioreactor conditions (pH, temperature) to maximize volumetric productivity and minimize batch cycle time, ensuring scalability and consistency. Defined, stable fermentation parameters validated for manufacturing readiness.
High-Purity Downstream Processing Utilizing specialized chromatography and crystallization techniques to efficiently separate L-fucose from the fermentation broth and remove closely related structural isomers. L-Fucose meets the specified purity profile for high-sensitivity applications.
Quality Control Comprehensive analytical testing, including HPLC, GC-MS, and structural analysis, to verify purity, stability, and structure. Deliver the final product.

Why Choose Us

L-Fucose (6-deoxy-L-galactose) is a functional deoxyhexose. It is a fundamental unit in fucosylation, a glycosylation reaction critical for cellular adhesion and signaling. L-Fucose synthesis service addresses the critical supply gap for this vital deoxyhexose. L-Fucose is a rare sugar found in human milk and glycans, performing key functions in antitumor immunity, inflammation, and gut health. Creative Biolabs leverages high-efficiency biocatalysis and metabolic engineering to secure this supply chain, enabling clients to integrate this powerful functional molecule into commercial products with confidence. It has various key applications:

Pharmaceuticals

Used to target abnormal fucosylation patterns often exhibited by cancer cells. It also acts as a sugary regulator, enhancing antitumor immunity.

Nutraceuticals

It is a human-identical milk monosaccharide. As part of fucosyllactose (HMOs), it is essential for the growth of beneficial infant gut bacteria, such as Bifidobacterium longum, and its fermentation yields 1,2-propanediol, a critical precursor for the beneficial short-chain fatty acid, Propionate.

Food industry

Potential use as an emulsifier and functional food ingredient.

Creative Biolabs stands at the forefront of functional glycan synthesis, offering a decisive advantage over conventional suppliers. Our expertise merges deep structural biology with cutting-edge metabolic engineering, ensuring we address the full scope of your challenges. We don't just supply L-fucose, we secure your entire product future.

Published Data

This research details the identification and thorough characterization of a novel L-fucose isomerase, designated RdFucI. The paper addresses the high-demand, low-supply challenge associated with L-fucose, a rare sugar used across the pharmaceutical, cosmetic, and food industries, which is typically difficult and costly to obtain through traditional extraction or multi-step chemical synthesis. The core finding is that RdFucI efficiently catalyzes the enzymatic interconversion between L-fucose (an aldose sugar) and its ketose counterpart, L-fuculose. Critically for industrial application, the enzyme's equilibrium strongly favors the production of L-fucose from L-fuculose, achieving an approximately 9:1 ratio in favor of L-fucose under standard conditions (30 °C and pH 7). This high yield demonstrates the enzyme's potential as a highly efficient biocatalyst for the mass production of the desired sugar.

A schematic diagram for L-fucose synthesis mediated by L-fucose isomerase. (OA Literature)Fig.2 A process for L-fucose synthesis mediated by L-fucose isomerase.1

FAQs

How does Creative Biolabs guarantee the purity of L-Fucose compared to algae extraction methods?

Algae extraction requires aggressive separation from complex polysaccharides, leading to inevitable contaminants. Our biocatalysis and metabolic engineering platforms achieve high purity because we build the molecule from the ground up in a controlled environment, resulting in a product with superior chemical definition and minimal unwanted structural isomers.

Can Creative Biolabs supply custom fucosylated oligosaccharides as well as the monosaccharide?

Yes. L-Fucose is a key building block. Our expertise extends to Oligosaccharide Synthesis, allowing us to utilize the L-Fucose we produce to synthesize specific fucosylated HMOs, such as 2'-FL and 3'-FL, using complementary enzymatic or microbial methods. Please see our website for more details on our HMO offerings.

What initial investment is required to start a custom synthesis project, and how long does it typically take?

The investment depends on the required purity and scale. Proof-of-concept projects typically start on a tiered basis. The typical timeframe for this service ranges from 8 to 16 weeks, depending on the target purity and scale-up complexity. We offer flexible service models. Please contact us for a detailed, project-specific proposal.

Customer Review

Purity and Speed
"Using Creative Biolabs' L-fucose synthesis service in our oncology research has significantly improved the speed of our fucosylated glycan array development. The consistent, low-endotoxin purity is unmatched by previous extraction-based suppliers, allowing us to publish faster." - Dr. T*ma, Scientist.

Scalability for Prebiotics
"Creative Biolabs solved our long-term supply bottleneck. We initially relied on expensive chemical synthesis, but their metabolic engineering process drastically reduced our COGS, making large-scale production of our new gut health product commercially viable." - A**n, Production Manager.

Customization and Traceability
"Their team didn't just sell us a product, they provided a customized enzymatic protocol for L-fucose production from an affordable precursor, complete with full batch traceability - essential for our regulatory audit process." - C**ra, Scientist.

Extended Services

Creative Biolabs offers a suite of complementary services to support your advanced functional glycans projects, often needed to fully realize the potential of the L-Fucose we supply:

Service Category Description
Custom Synthesis Custom synthesis and large-scale production of glycan, including Monosaccharide, Oligosaccharide, Polysaccharide, etc.
Custom Engineering Provide various Cell Line Glycoengineering services.
Carbohydrate Analysis Advanced detection technologies are used to support diverse carbohydrate analysis services.

How to Contact Us

Creative Biolabs is your expert partner in securing the industrial future of functional glycans. Our L-fucose synthesis service, built on proprietary metabolic engineering and biocatalysis platforms, guarantees the high-purity, scalable supply you need to capitalize on the multi-market potential of L-fucose in therapeutics, nutraceuticals, and cosmetics. Please contact us for more information.

Reference

  1. Kim InJung, Kim InJung, et al. "Enzymatic synthesis of L-fucose from L-fuculose using a fucose isomerase from Raoultella sp. and the biochemical and structural analyses of the enzyme." (2019): 5-December. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.1186/s13068-019-1619-0
For Research Use Only.

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