PIP3, diC8

Phosphoinositides (PIPs) are low-abundance membrane constituents that act as fundamental components of cellular signaling networks. Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is produced when PI 3-kinase phosphorylates PI(4,5)P2 and is a key driver for numerous downstream pathways, regulating critical functions like cell proliferation, growth, survival, protein synthesis, and glucose transport. Elevated PIP3 levels are often linked to dysregulated PI 3-K activity and observed in various inflammatory conditions and cancers. PIP3 is inactivated by phosphatases, including PTEN and SHIP. PI(3,4,5)P3 diC8 represents a high-purity, synthetic, dioctanoyl variant of PI(3,4,5)P3.

163563-77-7

Dioctanoyl phosphatidylinositol 3,4,5-trisphosphate; PtdIns(3,4,5)P3 (8:0/8:0); PI(3,4,5)P3 C8; PI(3,4,5)P3 diC8

C₂₅H₄₃Na₇O₂₂P₄

980.42

InChI=1S/C25H50O22P4.Na/c1-3-5-7-9-11-13-18(26)41-15-17(43-19(27)14-12-10-8-6-4-2)16-42-51(39,40)47-22-20(28)23(44-48(30,31)32)25(46-50(36,37)38)24(21(22)29)45-49(33,34)35;/h17,20-25,28-29H,3-16H2,1-2H3,(H,39,40)(H2,30,31,32)(H2,33,34,35)(H2,36,37,38);/t17-,20+,21+,22?,23-,24+,25?;/m1./s1

VNAYLXMADPLJAX-SCAASEOASA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.