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This is a long-chain (diC16) analog of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) that has been chemically modified at the phosphodiester bond to increase metabolic resistance. PI(4,5)P2 is a key signaling lipid that is normally rapidly hydrolyzed by phospholipases and phosphatases. This metabolically stable counterpart is an indispensable reagent for investigating PI(4,5)P2-regulated protein interactions and membrane dynamics without rapid degradation.