GlycoErase™ HEK293T UGGT1 Knockout Cell Line

For researchers investigating protein folding quality control, we are pleased to offer a UGGT1 knockout HEK293T cell line. This cell line, deficient in the UGGT1-encoded UDP-glucose glycoprotein glucosyltransferase 1, provides a unique opportunity to study the role of UGGT1 in reglucosylating unfolded glycoproteins in the endoplasmic reticulum. This model, within the context of HEK293T cells, a platform widely used for gene function and regulation studies, allows for in-depth analysis of UGGT1's contribution to protein folding quality control mechanisms.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293T

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

DMEM & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

UGGT1

UDP-glucose glycoprotein glucosyltransferase 1

HUGT1, UGCGL1

2q14.3

Quality control maestro of the endoplasmic reticulum, selectively reglucosylating unfolded glycoproteins to ensure proper protein folding and transport.