GlycoErase™ HEK293T UGGT1 Knockout Cell Line (CAT#: GLJF-0425-JF486)

Description	For researchers investigating protein folding quality control, we are pleased to offer a UGGT1 knockout HEK293T cell line. This cell line, deficient in the UGGT1-encoded UDP-glucose glycoprotein glucosyltransferase 1, provides a unique opportunity to study the role of UGGT1 in reglucosylating unfolded glycoproteins in the endoplasmic reticulum. This model, within the context of HEK293T cells, a platform widely used for gene function and regulation studies, allows for in-depth analysis of UGGT1's contribution to protein folding quality control mechanisms.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	2 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	UGGT1
Full Name	UDP-glucose glycoprotein glucosyltransferase 1
Alternative Name	HUGT1, UGCGL1
Location	2q14.3
Gene ID	56886
Summary	Quality control maestro of the endoplasmic reticulum, selectively reglucosylating unfolded glycoproteins to ensure proper protein folding and transport.