GlycoErase™ SIGLEC10 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF846)

Description	GlycoErase™ SIGLEC10 knockout HEK293 cell line is a human embryonic kidney cell line in which SIGLEC10 expression has been eliminated. SIGLECs are cell-surface receptors with ITIM motifs that transmit inhibitory signals, and SIGLEC10 is expressed on innate immune cells, regulating immune activation and homeostasis. The knockout of SIGLEC10 in the HEK293 background provides a flexible platform for studying inhibitory receptor signaling and innate immune regulation, with applications in immunology research, therapeutic antibody development, and viral studies.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC10
Full Name	Sialic Acid Binding Ig Like Lectin 10
Alternative Name	SLG2, PRO940, SIGLEC-10, Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	89790
Summary	SIGLECs, members of the immunoglobulin superfamily, are mainly expressed on innate immune cells, except for SIGLEC6, which is found on B-cells. Many SIGLECs contain one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs).