GlycoErase™ SIGLEC10 Knockout A549 Cell Line (CAT#: GLJF-0825-JF844)

Description	GlycoErase™ SIGLEC10 knockout A549 cell line is a human lung epithelial cancer model with SIGLEC10 expression deleted. SIGLECs are cell-surface receptors of the immunoglobulin superfamily, many of which contain immune receptor tyrosine-based inhibitory motifs (ITIMs) that transmit inhibitory signals. SIGLEC10, typically expressed on innate immune cells, participates in the modulation of immune activation and homeostasis. The elimination of SIGLEC10 in the A549 background provides a specialized tool to study inhibitory receptor signaling, innate immune regulation, and immune checkpoint biology, and supports applications in immunology research, drug discovery, and therapeutic antibody development.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:3~1:6
Cell Line	A549
Primary Disease	Non-small cell lung cancer
Lineage	Lung
Lineage Subtype	Non-small cell lung cancer

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	F-12K & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC10
Full Name	Sialic Acid Binding Ig Like Lectin 10
Alternative Name	SLG2, PRO940, SIGLEC-10, Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	89790
Summary	SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).