GlycoErase™ SIGLEC10 Knockout CHO-K1 Cell Line (CAT#: GLJF-0825-JF845)

Description	GlycoErase™ SIGLEC10 knockout CHO-K1 cell line is a CHO-K1 model lacking SIGLEC10 expression. SIGLECs are cell-surface receptors with ITIM motifs transmitting inhibitory signals. SIGLEC10 is expressed on innate immune cells and modulates immune activation and homeostasis. Removal of SIGLEC10 in CHO-K1 provides a specialized tool to study inhibitory receptor signaling, innate immune regulation, and immune checkpoint functions, supporting drug discovery, antibody development, and immunology research.
Product Type	KO Cell Lines
Species	Hamster
Cell Morphology	Epithelial, adherent
Passage Ratio	1:3~1:5
Cell Line	CHO-K1
Lineage	Chinese hamster ovary

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC10
Full Name	Sialic Acid Binding Ig Like Lectin 10
Alternative Name	SLG2, PRO940, SIGLEC-10, Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	89790
Summary	SIGLECs are members of the immunoglobulin superfamily and are expressed primarily on cells of the innate immune system, except for SIGLEC6, which is expressed on B-cells. Most SIGLECs contain one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs).