GlycoErase™ SIGLEC10 Knockout Jurkat Cell Line (CAT#: GLJF-0825-JF849)

Description	GlycoErase™ SIGLEC10 knockout Jurkat cell line is a Jurkat T cell line in which SIGLEC10 expression has been eliminated. SIGLECs are surface receptors with ITIM motifs transmitting inhibitory signals, and SIGLEC10 regulates immune activation and homeostasis. This knockout Jurkat model enables the study of inhibitory receptor pathways and T cell immune regulation, with applications in checkpoint inhibitor research, cytokine biology, and therapeutic antibody development.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Suspension-growing
Passage Ratio	1:3~1:5
Cell Line	Jurkat cell line
Primary Disease	T-cell acute lymphoblastic leukemia (T-ALL)
Lineage	T Lymphocyte
Lineage Subtype	T-cell acute lymphoblastic leukemia (T-ALL)

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC10
Full Name	Sialic Acid Binding Ig Like Lectin 10
Alternative Name	SLG2, PRO940, SIGLEC-10, Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	89790
Summary	SIGLECs are part of the immunoglobulin superfamily, predominantly expressed on innate immune cells. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs). The exception is SIGLEC6, expressed on B-cells.