GlycoFlux™ Human SIGLEC10 Overexpression HEK293 Cell Line (CAT#: GLJF-0925-JF846)

Description	GlycoFlux™ human SIGLEC10 overexpression HEK293 cell line is a stable cell line engineered to express SIGLEC10, a member of the immunoglobulin superfamily expressed mainly on innate immune cells. Containing ITIM motifs, it transduces inhibitory signals upon glycan binding. This model is ideal for examining sialylated glycan recognition, innate immune suppression, and the impact of glycosylation on receptor-ligand interactions in human cells.
Product Type	Overexpression Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & DMEM
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC10
Full Name	Sialic Acid Binding Ig Like Lectin 10
Alternative Name	SLG2, PRO940, SIGLEC-10, Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	89790
Summary	SIGLECs, members of the immunoglobulin superfamily, are mainly expressed on innate immune cells, except for SIGLEC6, which is found on B-cells. Many SIGLECs contain one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs).