GlycoFlux™ Human SIGLEC15 Overexpression Glycoengineered Cell (CAT#: GLJF-0925-JF128)

Description	GlycoFlux™ human SIGLEC15 overexpression glycoengineered cell is a stable cell line that constitutively overexpresses SIGLEC15, a membrane receptor implicated in osteoclast biology and tumor immune suppression. By editing cell-surface sialylation and co-receptor context, this platform supports osteoclastogenesis pathway studies, evaluation of anti-SIGLEC15 therapeutics, and deconvolution of myeloid checkpoint mechanisms.
Product Type	Overexpression Cell Lines
Cell Line	As requested by the client.

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC15
Full Name	Sialic Acid Binding Ig Like Lectin 15
Alternative Name	CD33L3; HsT1361; SIGLEC-15; Sialic Acid Binding Ig Like Lectin
Location	18q21.1
Gene ID	284266
Summary	Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane.