GlycoErase™ SIGLEC16 Knockout A549 Cell Line

GlycoErase™ SIGLEC16 knockout A549 cell line is a human lung epithelial cancer model in which SIGLEC16 expression has been removed. SIGLEC16 is predicted to act as a sialic acid-binding receptor, contributing to cell membrane localization and playing roles in the positive regulation of antibacterial defense responses and interleukin-6 production. Deletion of SIGLEC16 in the A549 background provides a distinct model for studying host-pathogen interactions, cytokine regulation, and innate immune activation, and supports applications in infectious disease research, inflammation studies, and therapeutic development.

KO Cell Lines

Human

Epithelial-like, adherent

1:3~1:6

A549

Non-small cell lung cancer

Lung

Non-small cell lung cancer

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

F-12K & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC16

Sialic Acid Binding Ig Like Lectin 16

SIGLECP16, Siglec-P16, Sialic Acid Binding Ig Like Lectin

19q13.33

Predicted to enable sialic acid binding activity. Involved in positive regulation of defense response to bacterium and positive regulation of interleukin-6 production. Predicted to be located in membrane. Predicted to be active in plasma membrane.