GlycoErase™ SIGLEC16 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF876)

Description	GlycoErase™ SIGLEC16 knockout HEK293 cell line is a HEK293 model with SIGLEC16 expression deleted. SIGLEC16 is a sialic acid-binding receptor that contributes to antibacterial defense responses and interleukin-6 regulation, and it is localized to the plasma membrane. The knockout HEK293 line provides a versatile model for exploring host-pathogen interactions, cytokine regulation, and innate immune activation, while supporting applications in infectious disease studies, viral biology, and antibody validation.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC16
Full Name	Sialic Acid Binding Ig Like Lectin 16
Alternative Name	SIGLECP16, Siglec-P16, Sialic Acid Binding Ig Like Lectin
Location	19q13.33
Gene ID	400709
Summary	This protein is predicted to bind sialic acid and is involved in the positive regulation of defense responses to bacteria and the production of interleukin-6. It is expected to be active in the plasma membrane.