GlycoErase™ SIGLEC16 Knockout HEK293 Cell Line

GlycoErase™ SIGLEC16 knockout HEK293 cell line is a HEK293 model with SIGLEC16 expression deleted. SIGLEC16 is a sialic acid-binding receptor that contributes to antibacterial defense responses and interleukin-6 regulation, and it is localized to the plasma membrane. The knockout HEK293 line provides a versatile model for exploring host-pathogen interactions, cytokine regulation, and innate immune activation, while supporting applications in infectious disease studies, viral biology, and antibody validation.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & Proline & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC16

Sialic Acid Binding Ig Like Lectin 16

SIGLECP16, Siglec-P16, Sialic Acid Binding Ig Like Lectin

19q13.33

This protein is predicted to bind sialic acid and is involved in the positive regulation of defense responses to bacteria and the production of interleukin-6. It is expected to be active in the plasma membrane.