0
Inquiry Basket

There is no product in the shopping cart, buy it!

GlycoFlux™ AAV1-Human ALG3 Viral Particle (CAT#: GLJF-1025-JF775)

Datasheet

SPECIFIC INQUIRY
Fluorescent Reporters:
Titer:
Size:
Add to basket
Description GlycoFlux™ AAV1-ALG3 Viral Particle expresses the α1,3-mannosyltransferase that extends Man5GlcNAc2-PP-Dol using Dol-P-Man, a key step implicated in CDG-Id modeling. The AAV1 backbone shows pronounced activity in CNS and heart with reliable delivery to liver, retina, pancreas, inner ear, and smooth muscle to facilitate in situ pathway interrogation.
Product Type Recombinant AAV1
Target ALG3
Species Human
Promotor CMV, CAG, TRE, or other promoters
Tissue Tropism Smooth muscle, Central Nervous System (CNS), Retina, Pancreas, Inner Ear, Heart, Liver
Packaging System AAV Triple-Plasmid Transfection System
Packaging Cell HEK293T
Application This AAV1 viral particle is primarily used for overexpressing target genes in muscle tissues (smooth muscle, heart) and the central nervous system (CNS) / sensory organs (retina, inner ear). It is an ideal tool for research and pre-clinical studies focused on myopathies, cardiac disorders, and certain neurological or sensory genetic diseases.
Shipping Shipped on dry ice, with temperature maintained at ≤ -80°C.
Storage Store at -80°C to preserve viral titer and stability.
Handling Notes Store this product at -80°C and minimize freeze-thaw cycles to preserve viral titer. For safety, handle in a certified biological safety cabinet and wear appropriate PPE (lab coat, gloves, and eye protection).
Product Disclaimer This product is intended for research use only and is not approved for diagnostic procedures or clinical applications. Users are solely responsible for implementing appropriate safety practices and complying with all applicable laws, regulations, and institutional policies. While Creative Biolabs is committed to rigorous quality control, no guarantee is made regarding performance in any particular assay or application.
Titer Assay qPCR/TCID50
Mycoplasma Test No mycoplasma contamination was detected.
Sterility Sterility testing verified the absence of microbial contamination.
Transduction Evaluation Upon request, Creative Biolabs performs in vitro or in vivo transduction assays to assess AAV delivery to target cells and to quantify transgene expression and function.
Insert Identity Confirmation All AAV preparations from Creative Biolabs are verified for vector-genome identity by PCR. In this assay, target cells are transduced with serial dilutions of the AAV preparation, harvested after a short incubation, and genomic DNA is isolated; a defined region of the packaged transgene is then PCR-amplified to confirm the expected sequence.
Full Name Alg3 Alpha-1,3- Mannosyltransferase
Alternative Name NOT56L; D16Ertd36e; CDGS4; Not56
Location 3q27.1
Gene ID 10195
Summary Key player in N-glycosylation, adding alpha 1,3 mannose (dol-P-Man to Man5GlcNAc2-PP-Dol); disruptions linked to CDG-Id (congenital disorder of glycosylation type Id), causing abnormal N-glycosylation and potential neurological issues.
For Research Use Only.
Online Inquiry
Creative Biolabs-Glycoprotein Follow us on
  • ()
    ()
    ()
ISO 9001 Certified - Creative Biolabs Quality Management System.