GlycoFlux™ Human SIGLEC16 Overexpression HepG2 Cell Line (CAT#: GLJF-0925-JF878)

Description	GlycoFlux™ human SIGLEC16 overexpression HepG2 cell line is a stable hepatocyte-derived model expressing SIGLEC16, a predicted sialic acid-binding lectin that regulates antibacterial defense and interleukin-6 production. Active at the plasma membrane, it links innate immune recognition with cytokine signaling. This model supports investigations of liver-associated immune defense and glycosylation-mediated lectin biology.
Product Type	Overexpression Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:4~1:6
Cell Line	HepG2
Primary Disease	Hepatoblastoma
Lineage	Liver
Lineage Subtype	Hepatoblastoma

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Glutamine
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC16
Full Name	Sialic Acid Binding Ig Like Lectin 16
Alternative Name	SIGLECP16, Siglec-P16, Sialic Acid Binding Ig Like Lectin
Location	19q13.33
Gene ID	400709
Summary	This protein is predicted to bind sialic acid and is involved in the positive regulation of defense responses to bacteria and the production of interleukin-6. It is predicted to be located in the membrane and active in the plasma membrane.