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This compound is a stable isotope-labeled standard of phosphatidylethanol (PEth), specifically featuring the 16:0/20:4 acyl composition with five deuterium atoms (D5) incorporated into the head group. Its robust isotopic signature makes it an ideal internal standard for rigorous, high-accuracy quantification of endogenous PEth in biological samples. It is indispensable for lipidomic analyses utilizing mass spectrometry (MS) to achieve reliable and matrix-independent measurement results.