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Recombinant Human GZMB protein (NP_004122.2) is produced in Sia-Increased Human Cell Line. This expression system is used for the production of glycoproteins with high sialylation with fucosylation.
The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing.