Recombinant Jaagsiekte sheep retrovirus (JSRV) Envelope glycoprotein (ENV), Baculovirus

Recombinant Jaagsiekte sheep retrovirus (JSRV) Envelope glycoprotein (NP_041188.1) was expressed in Baculovirus with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.

Determined by its binding ability in a functional ELISA.

Baculovirus

Jaagsiekte sheep retrovirus (JSRV)

His-tag or Tag free

>90%, determined by SDS-PAGE.

Unconjugated

ENV

Envelope glycoprotein

The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2.

Envelope glycoprotein; Env polyprotein; Surface protein; SU; Glycoprotein 52; gp52; Transmembrane protein; TM; Glycoprotein 36; gp36