Recombinant Marburg virus (MARV) Envelope glycoprotein (GP) (436-681 aa) [10xHis-tag and Myc-tag], Baculovirus (CAT#: GPX04-280J)

Product Overview	Recombinant Marburg virus (MARV) (strain West Germany/Popp/1967) ) Envelope glycoprotein (436-681 aa) was expressed in Baculovirus with a 10xHis-tag at the N-terminus and a Myc-tag at the C-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	Baculovirus
Species	Marburg virus (MARV) (strain West Germany/Popp/1967))
Fragment	436-681 aa
Sequence	SILWREGDMFPFLDGLINAPIDFDPVPNTKTIFDESSSSGASAEEDQHASPNISLTLSYFPNINENTAYSGENENDCDAELRIWSVQEDDLAAGLSWIPFFGPGIEGLYTAGLIKNQNNLVCRLRRLANQTAKSLELLLRVTTEERTFSLINRHAIDFLLTRWGGTCKVLGPDCCIGIEDLSRNISEQIDQIKKDEQKEGTGWGLGGKWWTSDWGVLTNLGILLLLSIAVLIALSCICRIFTKYIG
Tag	10xHis-tag at the N-terminus and Myc-tag at the C-terminus
Predicted MW	31.3 kDa
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	GP
Full Name	Envelope glycoprotein
Uniprot ID	P35254
Background	GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.
Alternate Names	Virion spike glycoprotein; GP; GP1; GP2