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Aminocardiolipin (ACL) is a structural analog of cardiolipin featuring a chemically modified small amine head group, making it crucial for membrane biophysics research. With its composition of four acyl chains, this derivative is frequently utilized as a stabilizing agent in the formulation of liposomes and lipid-based nanoparticles. Its distinct structure facilitates the investigation of complex lipid-protein interactions and the construction of stable, functional membrane systems for drug delivery or mechanistic studies.