GlycoErase™ SIGLEC14 Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF865)

Description	GlycoErase™ SIGLEC14 knockout HEK293T cell line is a HEK293T model in which SIGLEC14 expression has been eliminated. SIGLEC14 is predicted to mediate sialic acid binding, contribute to cell adhesion, and localize to granule membranes and the plasma membrane. This knockout HEK293T system provides a transiently transfectable model to investigate adhesion biology, innate immune activity, and membrane receptor function, and supports applications in viral production, molecular biology, and drug discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC14
Full Name	Sialic Acid Binding Ig Like Lectin 14
Alternative Name	Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	100049587
Summary	Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in ficolin-1-rich granule membrane and tertiary granule membrane. Predicted to be active in plasma membrane.