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GlycoErase™ SIGLEC7 Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF902

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ SIGLEC7 knockout HepG2 cell line is a human hepatocellular carcinoma line lacking SIGLEC7 expression. SIGLEC7 is predicted to function as a sialic acid-binding receptor involved in cell adhesion and is localized to the plasma membrane. The knockout HepG2 line offers a liver-relevant model to explore adhesion processes, glycan-mediated interactions, and membrane receptor biology, while supporting applications in cancer biology, viral entry research, and hepatology.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC7
Full Name
Sialic Acid Binding Ig Like Lectin 7
Alternative Name
p75, QA79, AIRM1, CD328, AIRM-1, CDw328, D-siglec, SIGLEC-7, SIGLECP2, SIGLEC19P, p75/AIRM1, Sialic Acid Binding Ig Like Lectin
Location
19q13.41
Gene ID
27036
Summary
The encoded protein is predicted to bind sialic acid and participate in cell adhesion. It is expected to be located in the membrane and to function actively within the plasma membrane.
For Research Use Only.
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