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GlycoErase™ SIGLEC10 Knockout Glycoengineered Cell

CAT#: GLJF-0825-JF124

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ SIGLEC10 knockout glycoengineered cell eliminates Siglec-10, an inhibitory immune receptor containing ITIM motifs and expressed on innate immune cells. This model supports studies of immune suppression and self-tolerance mechanisms.
Product Type
KO Cell Lines
Cell Line
As requested by the client.
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC10
Full Name
Sialic Acid Binding Ig Like Lectin 10
Alternative Name
SLG2; PRO940; SIGLEC-10; Sialic Acid Binding Ig Like Lectin
Location
19q13.41
Gene ID
89790
Summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
For Research Use Only.
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